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Back in 2005, a company called AstraZeneca came up with a new idea

m , The heat map illustrates relative abundance of the HECT domain-containing proteins identified in DIA-MS following SMART1 treatment

This ROS-driven cascade converges on microvascular dysfunctioncharacterized by dysregulated vasodilation, compromised endothelial barrier function, and increased vascular fragilityultimately manifesting as mucosal erosions and hemorrhage, the hallmark features of PHG [373]